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Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenografts

Lipid rafts are cholesterol- and sphingolipid-enriched microdomains in cell membranes that regulate phosphorylation cascades originating from membrane-bound proteins. In this study, we tested whether alteration of the cholesterol content of lipid rafts in prostate cancer (PCa) cell membranes affects...

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Détails bibliographiques
Auteurs principaux: Zhuang, Liyan, Kim, Jayoung, Adam, Rosalyn M., Solomon, Keith R., Freeman, Michael R.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2005
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1064980/
https://ncbi.nlm.nih.gov/pubmed/15776112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200519935
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