Mycobacterium tuberculosis with Disruption in Genes Encoding the Phosphate Binding Proteins PstS1 and PstS2 Is Deficient in Phosphate Uptake and Demonstrates Reduced In Vivo Virulence

By measuring phosphate uptake by Mycobacterium tuberculosis strains with the pstS1 and pstS2 genes genetically inactivated, we showed that these pstS genes encode high-affinity phosphate binding proteins. In a mouse infection model, both mutants were attenuated in virulence, suggesting that M. tuber...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Peirs, Priska, Lefèvre, Philippe, Boarbi, Samira, Wang, Xiao-Ming, Denis, Olivier, Braibant, Martine, Pethe, Kevin, Locht, Camille, Huygen, Kris, Content, Jean
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Molecular Pathogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1064925/
https://ncbi.nlm.nih.gov/pubmed/15731097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.3.1898-1902.2005
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados