Mycobacterium tuberculosis with Disruption in Genes Encoding the Phosphate Binding Proteins PstS1 and PstS2 Is Deficient in Phosphate Uptake and Demonstrates Reduced In Vivo Virulence

By measuring phosphate uptake by Mycobacterium tuberculosis strains with the pstS1 and pstS2 genes genetically inactivated, we showed that these pstS genes encode high-affinity phosphate binding proteins. In a mouse infection model, both mutants were attenuated in virulence, suggesting that M. tuber...

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Autori principali: Peirs, Priska, Lefèvre, Philippe, Boarbi, Samira, Wang, Xiao-Ming, Denis, Olivier, Braibant, Martine, Pethe, Kevin, Locht, Camille, Huygen, Kris, Content, Jean
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2005
Soggetti:
Molecular Pathogenesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1064925/
https://ncbi.nlm.nih.gov/pubmed/15731097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.3.1898-1902.2005
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