Expression analysis of three isoforms of hyaluronan synthase and hyaluronidase in the synovium of knees in osteoarthritis and rheumatoid arthritis by quantitative real-time reverse transcriptase polymerase chain reaction

Hyaluronan is a major molecule in joint fluid and plays a crucial role in joint motion and the maintenance of joint homeostasis. The concentration and average molecular weight of hyaluronan in the joint fluids are reduced in osteoarthritis and rheumatoid arthritis. To elucidate the underlying mechan...

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Bibliographic Details
Main Authors: Yoshida, Mamoru, Sai, Shigaku, Marumo, Keishi, Tanaka, Takaaki, Itano, Naoki, Kimata, Koji, Fujii, Katsuyuki
Format: Artigo
Language:Inglês
Published: BioMed Central 2004
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1064865/
https://ncbi.nlm.nih.gov/pubmed/15535829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar1223
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