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In Vitro Activities of Several Diaminomethylpyridopyrimidines against Mycobacterium avium Complex

Three recently synthesized dihydrofolate reductase (DHFR) inhibitors designated SoRI 8890, 8895, and 8897 were evaluated for their in vitro activities against 25 isolates of Mycobacterium avium complex. The MICs at which 50 and 90% of isolates were inhibited were 1 and 2, 4 and 8, and 4 and 8 μg/ml...

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Autors principals: Shoen, Carolyn M., Choromanska, Olga, Reynolds, Robert C., Piper, James R., Johnson, Cheryl A., Cynamon, Michael H.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 1998
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC106045/
https://ncbi.nlm.nih.gov/pubmed/9835537
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