Accumulation of Amphotericin B in Human Macrophages Enhances Activity against Aspergillus fumigatus Conidia: Quantification of Conidial Kill at the Single-Cell Level

A cytofluorometric assay that allowed assessment of damage to phagocytosed Aspergillus fumigatus conidia at the single-cell level was developed. After ingestion by monocyte-derived macrophages (MDMs), conidia were reisolated by treatment of the cells with streptolysin O, a pore-forming toxin with ly...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Jahn, Bernhard, Rampp, Albert, Dick, Christian, Jahn, Andreas, Palmer, Michael, Bhakdi, Sucharit
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1998
Assuntos:	Mechanisms of Action: Physiological Effects
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105899/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9756757/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.10.2569
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