Mechanism of Resistance to Amikacin and Kanamycin in Mycobacterium tuberculosis

An A1400G mutation of the rrs gene was identified in Mycobacterium tuberculosis (MTB) strain ATCC 35827 and in 13 MTB clinical isolates resistant to amikacin-kanamycin (MICs, >128 μg/ml). High-level cross-resistance may result from such a mutation since MTB has a single copy of the rrs gene. Anot...

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Bibliographic Details
Main Authors: Alangaden, George J., Kreiswirth, Barry N., Aouad, Arlette, Khetarpal, Minoo, Igno, Felicitas R., Moghazeh, Soraya L., Manavathu, Elias K., Lerner, Stephen A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1998
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC105813/
https://ncbi.nlm.nih.gov/pubmed/9593173
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