Molecular Basis of In Vivo Resistance to Sulfadoxine-Pyrimethamine in African Adult Patients Infected with Plasmodium falciparum Malaria Parasites

In vitro sulfadoxine and pyrimethamine resistance has been associated with point mutations in the dihydropteroate synthase and dihydrofolate reductase domains, respectively, but the in vivo relevance of these point mutations has not been well established. To analyze the correlation between genotype...

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Bibliografiske detaljer
Main Authors: Basco, Leonardo K., Tahar, Rachida, Ringwald, Pascal
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 1998
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC105688/
https://ncbi.nlm.nih.gov/pubmed/9661026
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