Antiproliferative Effects and Mechanism of Action of SCH 56592 against Trypanosoma (Schizotrypanum) cruzi: In Vitro and In Vivo Studies

We have investigated the antiproliferative effects of SCH 56592, a new experimental triazole, against Trypanosoma (Schizotrypanum) cruzi, the etiological agent of Chagas’ disease in Latin America. SCH 56592 blocked the proliferation of the epimastigote form of the parasite in vitro at 30 nM, a conce...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Urbina, Julio A., Payares, Gilberto, Contreras, Lellys M., Liendo, Andreína, Sanoja, Cristina, Molina, Judith, Piras, Marta, Piras, Romano, Perez, Norma, Wincker, Patrick, Loebenberg, David
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1998
Soggetti:	Mechanisms of Action: Physiological Effects
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105681/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9661019/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.7.1771
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