Antiproliferative Effects and Mechanism of Action of SCH 56592 against Trypanosoma (Schizotrypanum) cruzi: In Vitro and In Vivo Studies

We have investigated the antiproliferative effects of SCH 56592, a new experimental triazole, against Trypanosoma (Schizotrypanum) cruzi, the etiological agent of Chagas’ disease in Latin America. SCH 56592 blocked the proliferation of the epimastigote form of the parasite in vitro at 30 nM, a conce...

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izdano v:	Antimicrob Agents Chemother
Principais autores:	Urbina, Julio A., Payares, Gilberto, Contreras, Lellys M., Liendo, Andreína, Sanoja, Cristina, Molina, Judith, Piras, Marta, Piras, Romano, Perez, Norma, Wincker, Patrick, Loebenberg, David
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology (ASM) 1998
Teme:	Mechanisms of Action: Physiological Effects
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105681/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9661019/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.7.1771
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