Amino Acid Substitutions in the Cytochrome P-450 Lanosterol 14α-Demethylase (CYP51A1) from Azole-Resistant Candida albicans Clinical Isolates Contribute to Resistance to Azole Antifungal Agents

The cytochrome P-450 lanosterol 14α-demethylase (CYP51A1) of yeasts is involved in an important step in the biosynthesis of ergosterol. Since CYP51A1 is the target of azole antifungal agents, this enzyme is potentially prone to alterations leading to resistance to these agents. Among them, a decreas...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Sanglard, Dominique, Ischer, Françoise, Koymans, Luc, Bille, Jacques
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1998
Soggetti:	Mechanisms of Resistance
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105395/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9527767/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.2.241
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