Cloning of neuronal mtDNA variants in cultured cells by synaptosome fusion with mtDNA-less cells

Synaptosome cybrids were used to confirm the presence of heteroplasmic mtDNA sequence variants in the human brain. Synaptosomes contain one to several mitochondria, and when fused to mtDNA-deficient (ρ°) mouse or human cell lines result in viable cybrid cell lines. The brain origin of mouse synaptos...

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Bibliografiske detaljer

Udgivet i:	Nucleic Acids Res
Principais autores:	Trounce, Ian, Schmiedel, Janet, Yen, Hsiu-Chuan, Hosseini, Seyed, Brown, Michael D., Olson, Jeffrey J., Wallace, Douglas C.
Format:	Artigo
Sprog:	Inglês
Udgivet:	Oxford University Press 2000
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105374/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10773087/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.10.2164
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