Arterial and renal consequences of partial genetic deficiency in tissue kallikrein activity in humans

Tissue kallikrein (TK), the major kinin-forming enzyme, is synthesized in several organs, including the kidney and arteries. A loss-of-function polymorphism of the human TK gene (R53H) induces a substantial decrease in enzyme activity. As inactivation of the TK gene in the mouse induces endothelial...

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Main Authors: Azizi, Michel, Boutouyrie, Pierre, Bissery, Alvine, Agharazii, Mohsen, Verbeke, Francis, Stern, Nora, Bura-Rivière, Alessandra, Laurent, Stéphane, Alhenc-Gelas, François, Jeunemaitre, Xavier
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1052005/
https://ncbi.nlm.nih.gov/pubmed/15765151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200523669
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