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Homozygosity for a new mutation (Ile119-->Met) in the insulin receptor gene in five sibs with familial insulin resistance.

Mutations in the insulin receptor gene can cause genetic syndromes such as leprechaunism that are associated with extreme insulin resistance. We have investigated a patient with leprechaunism born of a consanguineous marriage. All 22 exons of the insulin receptor gene were screened for mutations usi...

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Main Authors: Hone, J, Accili, D, al-Gazali, L I, Lestringant, G, Orban, T, Taylor, S I
格式: Artigo
語言:Inglês
出版: 1994
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1050083/
https://ncbi.nlm.nih.gov/pubmed/7815442
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