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Human Papillomavirus Type 16 E7 DNA Vaccine: Mutation in the Open Reading Frame of E7 Enhances Specific Cytotoxic T-Lymphocyte Induction and Antitumor Activity

A human papillomavirus type 16 E7 DNA vaccine with the open reading frame encoding mutations in two zinc-binding motifs expressed a rapidly degraded E7 protein. This vaccine induced a significantly stronger E7-specific cytotoxic T-lymphocyte response and better tumor protection in mice than did a wi...

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Detaylı Bibliyografya
Asıl Yazarlar: Shi, Wei, Bu, Ping, Liu, Jianzhong, Polack, Axel, Fisher, Susan, Qiao, Liang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 1999
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC104321/
https://ncbi.nlm.nih.gov/pubmed/10438884
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