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The E7 Oncoprotein of Human Papillomavirus Type 16 Stabilizes p53 through a Mechanism Independent of p19(ARF)

High-risk human papillomaviruses are causally associated with cervical cancer. Two viral oncogenes, E6 and E7, are expressed in most cervical cancers, and these genes cause cancer when expressed in experimental animals. The E6 protein targets the p53 tumor suppressor for degradation, while the E7 pr...

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Bibliografiske detaljer
Main Authors: Seavey, Scott E., Holubar, Marisa, Saucedo, Leslie J., Perry, Mary Ellen
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 1999
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC104286/
https://ncbi.nlm.nih.gov/pubmed/10438849
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