Simultaneous Infection with Retroviruses Pseudotyped with Different Envelope Proteins Bypasses Viral Receptor Interference Associated with Colocalization of gp70 and Target Cells on Fibronectin CH-296

Several factors are thought to limit the efficiency of retroviral transduction in clinical gene therapy protocols that target hematopoietic stem cells. For example, the level of expression of the amphotropic receptor Pit-2, a phosphate symporter, appears to be low in human and murine hematopoietic s...

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Autors principals: MacNeill, Emily C., Hanenberg, Helmut, Pollok, Karen E., van der Loo, Johannes C. M., Bierhuizen, Marti F. A., Wagemaker, Gerard, Williams, David A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 1999
Matèries:
Gene Therapy
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC104174/
https://ncbi.nlm.nih.gov/pubmed/10196291
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