Expression of Murine Coronavirus Recombinant Papain-Like Proteinase: Efficient Cleavage Is Dependent on the Lengths of both the Substrate and the Proteinase Polypeptides

Proteolytic processing of the replicase gene product of mouse hepatitis virus (MHV) is essential for viral replication. In MHV strain A59 (MHV-A59), the replicase gene encodes two predicted papain-like proteinase (PLP) domains, PLP-1 and PLP-2. Previous work using viral polypeptide substrates synthe...

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Bibliografische Detailangaben

Veröffentlicht in:	J Virol
Hauptverfasser:	Teng, Henry, Piñón, Josefina D., Weiss, Susan R.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1999
Schlagworte:	Replication
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC104021/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10074111/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.4.2658-2666.1999
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