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Complementation of defective translesion synthesis and UV light sensitivity in xeroderma pigmentosum variant cells by human and mouse DNA polymerase η

Defects in the human gene XPV result in the variant form of the genetic disease xeroderma pigmentosum (XP-V). XPV encodes DNA polymerase η, a novel DNA polymerase that belongs to the UmuC/DinB/Rad30 superfamily. This polymerase catalyzes the efficient and accurate translesion synthesis of DNA past c...

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Udgivet i:Nucleic Acids Res
Principais autores: Yamada, Ayumi, Masutani, Chikahide, Iwai, Shigenori, Hanaoka, Fumio
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2000
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC102698/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10871396/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.13.2473
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