Identification of sequence motifs in oligonucleotides whose presence is correlated with antisense activity

Design of antisense oligonucleotides targeting any mRNA can be much more efficient when several activity-enhancing motifs are included and activity-decreasing motifs are avoided. This conclusion was made after statistical analysis of data collected from >1000 experiments with phosphorothioate-modifi...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Matveeva, O. V., Tsodikov, A. D., Giddings, M., Freier, S. M., Wyatt, J. R., Spiridonov, A. N., Shabalina, S. A., Gesteland, R. F., Atkins, J. F.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 2000
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC102688/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10908347/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.15.2862
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