The GAA•TTC triplet repeat expanded in Friedreich’s ataxia impedes transcription elongation by T7 RNA polymerase in a length and supercoil dependent manner
Large expansions of the trinucleotide repeat GAA•TTC within the first intron of the X25 (frataxin) gene cause Friedreich’s ataxia, the most common inherited ataxia. Expansion leads to reduced levels of frataxin mRNA in affected individuals. Here we show that GAA•TTC tracts, in the absence of any oth...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Nucleic Acids Res |
|---|---|
| Prif Awduron: | , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
Oxford University Press
2000
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC102661/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10908340/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.14.2815 |
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