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The dhfr oriβ-binding protein RIP60 contains 15 zinc fingers: DNA binding and looping by the central three fingers and an associated proline-rich region

Initiation of DNA replication occurs with high frequency within oriβ, a short region 3′ to the Chinese hamster dhfr gene. Homodimers of RIP60 (replication initiation-region protein 60 kDA) purified from nuclear extract bind two ATT-rich sites in oriβ and foster the formation of a twisted 720 bp DNA...

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Udgivet i:Nucleic Acids Res
Principais autores: Houchens, Christopher R., Montigny, William, Zeltser, Lori, Dailey, Lisa, Gilbert, Jonathan M., Heintz, N. H.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2000
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC102514/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10606657/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.2.570
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