Rat Protein Tyrosine Phosphatase η Suppresses the Neoplastic Phenotype of Retrovirally Transformed Thyroid Cells through the Stabilization of p27(Kip1)

The r-PTPη gene encodes a rat receptor-type protein tyrosine phosphatase whose expression is negatively regulated by neoplastic cell transformation. Here we first demonstrate a dramatic reduction in DEP-1/HPTPη (the human homolog of r-PTPη) expression in a panel of human thyroid carcinomas. Subseque...

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Detalhes bibliográficos
Main Authors: Trapasso, Francesco, Iuliano, Rodolfo, Boccia, Angelo, Stella, Antonella, Visconti, Roberta, Bruni, Paola, Baldassarre, Gustavo, Santoro, Massimo, Viglietto, Giuseppe, Fusco, Alfredo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC102181/
https://ncbi.nlm.nih.gov/pubmed/11094075
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