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p53 Binds Selectively to the 5′ Untranslated Region of cdk4, an RNA Element Necessary and Sufficient for Transforming Growth Factor β- and p53-Mediated Translational Inhibition of cdk4

One consequence of transforming growth factor β (TGF-β) treatment is inhibition of Cdk4 synthesis, and this is dependent on p53. Here, we show that the 5′ untranslated region (UTR) of the cdk4 mRNA is both necessary and sufficient for wild-type p53-dependent TGF-β-regulated translational inhibition...

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Udgivet i:Mol Cell Biol
Principais autores: Miller, Susan J., Suthiphongchai, Tuangporn, Zambetti, Gerard P., Ewen, Mark E.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2000
Fag:
Cell Growth and Development
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC102149/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11046139/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.22.8420-8431.2000
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