Helicase and Capping Enzyme Active Site Mutations in Brome Mosaic Virus Protein 1a Cause Defects in Template Recruitment, Negative-Strand RNA Synthesis, and Viral RNA Capping

Brome mosaic virus (BMV) encodes two RNA replication proteins: 1a, which contains RNA capping and helicase-like domains, and 2a, which is related to polymerases. BMV 1a and 2a can direct virus-specific RNA replication in the yeast Saccharomyces cerevisiae, which reproduces the known features of BMV...

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Bibliografische Detailangaben

Veröffentlicht in:	J Virol
Hauptverfasser:	Ahola, Tero, den Boon, Johan A., Ahlquist, Paul
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2000
Schlagworte:	Replication
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC102074/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10982322/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.19.8803-8811.2000
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