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Processing of nucleopeptides mimicking the topoisomerase I–DNA covalent complex by tyrosyl-DNA phosphodiesterase

Tyrosyl-DNA phosphodiesterase-1 (Tdp1) is the only known enzyme to remove tyrosine from complexes in which the amino acid is linked to the 3′-end of DNA fragments. Such complexes can be produced following DNA processing by topoisomerase I, and recent studies in yeast have demonstrated the importance...

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Udgivet i:Nucleic Acids Res
Principais autores: Debéthune, Laurent, Kohlhagen, Glenda, Grandas, Anna, Pommier, Yves
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2002
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC101246/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11861912/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/30.5.1198
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