Inhibition by prostaglandin E1 and E2 of 1,25-dihydroxyvitamin D3 synthesis by synovial fluid macrophages from arthritic joints.

Previous work has shown that renal metabolism of 25-dihydroxyvitamin D3 (25(OH)D3) to the active metabolite, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) is stimulated by prostaglandin E2 and inhibited by acetylsalicylate (aspirin). As prostaglandins are primary inflammatory mediators and synovial fluid m...

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Detalhes bibliográficos

Publicado no:	Ann Rheum Dis
Principais autores:	Hayes, M E, Rai, A, Cooper, R G, Bayley, D, Freemont, A J, Mawer, E B
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMJ Publishing Group 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC1005696/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1616328/ https://ncbi.nlm.nih.govhttps://doi.org/10.1136/ard.51.5.632
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