Non-Watson–Crick interactions between PNA and DNA inhibit the ATPase activity of bacteriophage T4 Dda helicase

Peptide nucleic acid (PNA) is a DNA mimic in which the nucleobases are linked by an N-(2-aminoethyl) glycine backbone. Here we report that PNA can interact with single-stranded DNA (ssDNA) in a non-sequence-specific fashion. We observed that a 15mer PNA inhibited the ssDNA-stimulated ATPase activity...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Tackett, Alan J., Corey, David R., Raney, Kevin D.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 2002
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC100347/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11842106/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/30.4.950
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