Socs-1 Inhibits TEL-JAK2-Mediated Transformation of Hematopoietic Cells through Inhibition of JAK2 Kinase Activity and Induction of Proteasome-Mediated Degradation

TEL-JAK2 fusion proteins, which are a result of t(9;12)(p24;p13) translocations associated with human leukemia, activate Stat5 in vitro and in vivo and cause a myelo- and lymphoproliferative disease in a murine bone marrow transplant model. We report that Socs-1, a member of the SOCS family of endog...

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Главные авторы: Frantsve, Julie, Schwaller, Juerg, Sternberg, David W., Kutok, Jeffery, Gilliland, D. Gary
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2001
Предметы:
Cell Growth and Development
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC100276/
https://ncbi.nlm.nih.gov/pubmed/11313480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.10.3547-3557.2001
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