Nerve Growth Factor Stimulates Multisite Tyrosine Phosphorylation and Activation of the Atypical Protein Kinase C's via a src Kinase Pathway

Atypical protein kinase C (PKC) isoforms are required for nerve growth factor (NGF)-initiated differentiation of PC12 cells. In the present study, we report that PKC-ι becomes tyrosine phosphorylated in the membrane coincident with activation posttreatment with nerve growth factor. Tyrosine phosphor...

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Bibliographic Details
Main Authors: Wooten, Marie W., Vandenplas, Michel L., Seibenhener, M. Lamar, Geetha, Thangiah, Diaz-Meco, Maria T.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC100005/
https://ncbi.nlm.nih.gov/pubmed/11713277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.24.8414-8427.2001
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