Lung tumor exosomes induce a pro-inflammatory phenotype in mesenchymal stem cells via NFκB-TLR signaling pathway

Abstract Background In tumor microenvironment, a continuous cross-talk between cancer cells and other cellular components is required to sustain tumor progression. Accumulating evidence suggests that exosomes, a novel way of cell communication, play an important role in such cross-talk. Exosomes cou...

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Main Authors: Xiaoxia Li, Shihua Wang, Rongjia Zhu, Hongling Li, Qin Han, Robert Chunhua Zhao
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2016-04-01
Colecção:Journal of Hematology & Oncology
Assuntos:
Exosomes
MSCs
Tumor-supportive
Inflammation
NF-κB
TLR2
Acesso em linha:http://link.springer.com/article/10.1186/s13045-016-0269-y
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