Therapeutic approaches to genetic ion channelopathies and perspectives in drug discovery

In the human genome more than 400 genes encode ion channels, which are transmembrane proteins mediating ion fluxes across membranes. Being expressed in all cell types, they are involved in almost all physiological processes, including sense perception, neurotransmission, muscle contraction, secretio...

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Autori principali: Paola eImbrici, Antonella eLiantonio, Giulia Maria eCamerino, Michela eDe Bellis, Claudia eCamerino, Antonietta eMele, Arcangela eGiustino, Sabata ePierno, Annamaria eDe Luca, Domenico eTricarico, Jean-Francois eDesaphy, Diana eConte
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2016-05-01
Serie:Frontiers in Pharmacology
Soggetti:
Channelopathies
Genetics
Drug discovery and development
ion channels pharmacology
Physiopathology
Accesso online:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00121/full
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