Identifying causal genes for stroke via integrating the proteome and transcriptome from brain and blood

Abstract Background Genome-wide association studies (GWAS) have revealed numerous loci associated with stroke. However, the underlying mechanisms at these loci in the pathogenesis of stroke and effective stroke drug targets are elusive. Therefore, we aimed to identify causal genes in the pathogenesi...

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Detalhes bibliográficos
Main Authors: Bang-Sheng Wu, Shu-Fen Chen, Shu-Yi Huang, Ya-Nan Ou, Yue-Ting Deng, Shi-Dong Chen, Qiang Dong, Jin-Tai Yu
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2022-04-01
Colecção:Journal of Translational Medicine
Assuntos:
Stroke
Proteome-wide association study
Transcriptome-wide association study
Mendelian randomization
Bayesian colocalization
Acesso em linha:https://doi.org/10.1186/s12967-022-03377-9
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