Are sperm capacitation and apoptosis the opposite ends of a continuum driven by oxidative stress?

This chapter explores the possibility that capacitation and apoptosis are linked processes joined by their common dependence on the continued generation of reactive oxygen species (ROS). According to this model capacitation is initiated in spematozoa following their release into the female reproduct...

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Bibliographic Details
Main Authors: Robert J Aitken, Mark A Baker, Brett Nixon
Format: Artigo
Language:Inglês
Published: Wolters Kluwer Medknow Publications 2015-01-01
Series:Asian Journal of Andrology
Subjects:
gene regulation
Musashi
Musashi-1
Musashi-2
posttranscriptional control
RNA binding proteins
spermatogenesis
splicing
testis
translation
cell fate
cell stress
importin
karyopherin
nucleocytoplasmic transport
spermatid
spermatocyte
artificial insemination
biomarker
fertility
fertilization
flow cytometry
infertility
nanotechnology
oocyte activation
Postacrosomal Sheath WWI Domain Binding Protein
sperm
SPTRX3
thioredoxin
ubiquitin
ATP binding cassette transporters
albumin
high-density lipoprotein
lipid rafts
membrane fluidity
membrane microdomains
membrane packing
oxysterols
reverse cholesterol transport
sterol transporters
egg
heat shock protein A2
molecular chaperone
sperm-egg interactions
dehydrogenases
oxidases
peroxiredoxins
reactive oxygen species
spermatozoa
thiols
thioredoxins
antigen-presenting cells
autoimmunity
dendritic cells
epididymis
macrophages
peripheral tolerance
sperm maturation
genomics
male infertility
proteomics
sperm chromatin
sperm epigenetics
sperm DNA damage
paternal genome
offspring
chemotaxis
rheotaxis
sperm behavior
sperm motility
thermotaxis
apoptosis
sperm capacitation
Online Access:http://www.ajandrology.com/article.asp?issn=1008-682X;year=2015;volume=17;issue=4;spage=633;epage=639;aulast=Aitken
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