UPLC-MS/MS for simultaneous quantification of vortioxetine and its metabolite Lu AA34443 in rat plasma and its application to drug interactions

Vortioxetine is currently used as the first-line therapy drug for major depressive disorder (MDD). In the present study, we aimed to develop and fully validate an ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for the simultaneous quantification of vortioxetine...

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Main Authors: Er-Min Gu, Yuanyuan Shao, Wei-Feng Xu, Lei Ye, Ren-ai Xu
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020-11-01
Colecção:Arabian Journal of Chemistry
Assuntos:
Vortioxetine
Lu AA34443
Pharmacokinetic interaction
UPLC-MS/MS
Inhibitory effect
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S1878535220303907
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