COP9 Signalosome Interaction with UspA/Usp15 Deubiquitinase Controls VeA-Mediated Fungal Multicellular Development

COP9 signalosome (CSN) and Den1/A deneddylases physically interact and promote multicellular development in fungi. CSN recognizes Skp1/cullin-1/Fbx E3 cullin-RING ligases (CRLs) without substrate and removes their posttranslational Nedd8 modification from the cullin scaffold. This results in CRL com...

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Bibliografske podrobnosti
Main Authors: Cindy Meister, Karl G. Thieme, Sabine Thieme, Anna M. Köhler, Kerstin Schmitt, Oliver Valerius, Gerhard H. Braus
Format: Artigo
Jezik:Inglês
Izdano: MDPI AG 2019-06-01
Serija:Biomolecules
Teme:
deubiquitination
ubiquitin-specific protease
Usp15/UspA
ubiquitin
Fbx23
COP9 signalosome (CSN)
<i>Aspergillus nidulans</i>
fungal development
secondary metabolism
velvet domain proteins
Online dostop:https://www.mdpi.com/2218-273X/9/6/238
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