Modulation of osmotic stress-induced TRPV1 expression rescues human iPSC-derived retinal ganglion cells through PKA

Abstract Background Transient receptor potential vanilloid 1 (TRPV1), recognized as a hyperosmolarity sensor, is a crucial ion channel involved in the pathogenesis of neural and glial signaling. Recently, TRPV1 was determined to play a role in retinal physiology and visual transmission. In this stud...

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Main Authors: Chih-Chien Hsu, Ke-Hung Chien, Aliaksandr A. Yarmishyn, Waradee Buddhakosai, Wen-Ju Wu, Tai-Chi Lin, Shih-Hwa Chiou, Jiann-Torng Chen, Chi-Hsien Peng, De-Kuang Hwang, Shih-Jen Chen, Yuh-Lih Chang
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-09-01
Colecção:Stem Cell Research & Therapy
Assuntos:
TRPV1
PKA
Osmotic stress
Human-induced pluripotent stem cells
hiPSC
Retinal ganglion cells
Acesso em linha:http://link.springer.com/article/10.1186/s13287-019-1363-1
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