Transcriptome-Wide Association Studies and Integration Analysis of mRNA Expression Profiles Identify Candidate Genes and Pathways Associated With Ankylosing Spondylitis

This study aimed to identify susceptibility genes and pathways associated with ankylosing spondylitis (AS) by integrating whole transcriptome-wide association study (TWAS) analysis and mRNA expression profiling data. AS genome-wide association study (GWAS) summary data from the large GWAS database w...

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Detalhes bibliográficos
Main Authors: Ruoyang Feng, Mengnan Lu, Lin Liu, Ke Xu, Peng Xu
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-05-01
Colecção:Frontiers in Immunology
Assuntos:
ankylosing spondylitis
genome-wide association study (GWAS)
transcriptome-wide association study (TWAS)
mRNA expression profile
susceptibility genes
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2022.814303/full
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