Intratumoral genetic and immune microenvironmental heterogeneity in T4N0M0 (diameter ≥ 7 cm) non‐small cell lung cancers

Abstract Background Starting with low metastatic capability, T4N0M0 (diameter ≥ 7 cm) non‐small cell lung cancers (NSCLCs) constitute a unique tumor subset, as with a large tumor size but no regional or distant metastases. We systematically investigated intratumoral heterogeneity, clonal structure,...

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Autori principali: Jia−Tao Zhang, Song Dong, Li−Yan Ji, Jia−Ying Zhou, Zhi− Hong Chen, Jian Su, Qing−Ge Zhu, Meng−Min Wang, E−E. Ke, Hao Sun, Xue−Tao Li, Jin−Ji Yang, Qing Zhou, Xu− Chao Zhang, Xuan Gao, Xue−Ning Yang, Xuefeng Xia, Xin Yi, Wen−Zhao Zhong, Yi−Long Wu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Wiley 2022-05-01
Serie:Thoracic Cancer
Soggetti:
chromosomal instability
clonal structure
immune microenvironment
intratumoral heterogeneity
metastasis
Accesso online:https://doi.org/10.1111/1759-7714.14393
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