Early Post-Vaccination Gene Signatures Correlate With the Magnitude and Function of Vaccine-Induced HIV Envelope-Specific Plasma Antibodies in Infant Rhesus Macaques

A better understanding of the impact of early innate immune responses after vaccine priming on vaccine-elicited adaptive immune responses could inform rational design for effective HIV vaccines. The current study compared the whole blood molecular immune signatures of a 3M-052-SE adjuvanted HIV Env...

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Main Authors: K. K. Vidya Vijayan, Kaitlyn A. Cross, Alan D. Curtis, Koen K. A. Van Rompay, Justin Pollara, Christopher B. Fox, Mark Tomai, Tomáš Hanke, Genevieve Fouda, Michael G. Hudgens, Sallie R. Permar, Kristina De Paris
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-04-01
Colecção:Frontiers in Immunology
Assuntos:
systems biology
innate gene signatures
vaccine-induced antibody response
early life HIV vaccine
rhesus macaque model
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2022.840976/full
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