A new method to detect loss of heterozygosity using cohort heterozygosity comparisons

<p>Abstract</p> <p>Background</p> <p>Loss of heterozygosity (LOH) is an important marker for one of the 'two-hits' required for tumor suppressor gene inactivation. Traditional methods for mapping LOH regions require the comparison of both tumor and patient-mat...

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Bibliographic Details
Main Authors: Lea Rod A, Wellwood Jeremy, Wood Peter, Jardine Paul, Green Michael R, Marlton Paula, Griffiths Lyn R
Format: Artigo
Language:Inglês
Published: BMC 2010-05-01
Series:BMC Cancer
Online Access:http://www.biomedcentral.com/1471-2407/10/195
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