Heterogeneous Contributing Factors in MPM Disease Development and Progression: Biological Advances and Clinical Implications

Malignant pleural mesothelioma (MPM) tumors are remarkably aggressive and most patients only survive for 5–12 months; irrespective of stage; after primary symptoms appear. Compounding matters is that MPM remains unresponsive to conventional standards of care; including radiation and chemotherapy. Cu...

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Hauptverfasser: Bhairavi Tolani, Luis A. Acevedo, Ngoc T. Hoang, Biao He
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2018-01-01
Schriftenreihe:International Journal of Molecular Sciences
Schlagworte:
malignant pleural mesothelioma (MPM)
tumor microenvironment heterogeneity
molecular pathways
tumor suppressors
immunotherapy
developmental cell pathways
Online Zugang:http://www.mdpi.com/1422-0067/19/1/238
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