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Perivascular adipose tissue inhibits endothelial function of rat aortas via caveolin-1.

Perivascular adipose tissue (PVAT)-derived factors have been proposed to play an important role in the pathogenesis of atherosclerosis. Caveolin-1 (Cav-1), occupying the calcium/calmodulin binding site of endothelial NO synthase (eNOS) and then inhibiting nitric oxide (NO) production, is also involv...

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Autors principals: Michelle Hui-Hsin Lee, Shiu-Jen Chen, Cheng-Ming Tsao, Chin-Chen Wu
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science (PLoS) 2014-01-01
Col·lecció:PLoS ONE
Accés en línia:http://europepmc.org/articles/PMC4057398?pdf=render
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