SORBS2 as a molecular target for atherosclerosis in patients with familial hypercholesterolemia

Abstract Background Familial hypercholesterolemia (FH) is a metabolic disease in which patients are prone to develop premature atherosclerosis (AS). Sorbin and SH3 Domain Containing 2 (SORBS2) is known to play a role in coronary heart disease (CHD). However, the mechanism underlying SORBS2 involveme...

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Main Authors: Ming-Ming Liu, Jia Peng, Yuan-Lin Guo, Cheng-Gang Zhu, Na-Qiong Wu, Rui-Xia Xu, Qian Dong, Chuan-Jue Cui, Jian-Jun Li
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2022-05-01
Series:Journal of Translational Medicine
Assuntos:
SORBS2
Oxidized low density lipoprotein
NLRP3 inflammasome
ROS
Cholesterol efflux
Acceso en liña:https://doi.org/10.1186/s12967-022-03381-z
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