Understanding Regulatory Mechanisms of Brain Function and Disease through 3D Genome Organization

The human genome has a complex and dynamic three-dimensional (3D) organization, which plays a critical role for gene regulation and genome function. The importance of 3D genome organization in brain development and function has been well characterized in a region- and cell-type-specific fashion. Rec...

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Main Authors: Weifang Liu, Wujuan Zhong, Jiawen Chen, Bo Huang, Ming Hu, Yun Li
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2022-03-01
Series:Genes
Assuntos:
chromosome conformation capture (3C)
human genome
brain function and disease
topologically associating domain (TAD)
frequently interacting region (FIRE)
chromatin interaction
Acceso en liña:https://www.mdpi.com/2073-4425/13/4/586
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