Emergence and Persistence of Resistance-Associated Substitutions in HCV GT3 Patients Failing Direct-Acting Antivirals

Background: The hepatitis C virus has a high mutation rate, which results in the emergence of resistance-associated substitutions (RASs). Despite direct-acting antivirals (DAAs) efforts to treat chronically infected HCV genotype 3 (GT3) patients, there are concerns about the emergence and persistenc...

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Main Authors: Saima Mushtaq, Asraf Hussain Hashmi, Amjad Khan, Syed Muhammad Asad Raza Kazmi, Sobia Manzoor
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-04-01
Serier:Frontiers in Pharmacology
Fag:
hepatitis C virus
genotype 3
direct-acting antiviral
relapse
resistance-associated substitutions
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2022.894460/full
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