The Interplay Between Biliary Occlusion and Liver Regeneration: Repeated Regeneration Stimuli Restore Biliary Drainage by Promoting Hepatobiliary Remodeling in a Rat Model

Background and AimsPatients with malignant biliary obstruction do not seem to benefit from “two-stage hepatectomy” due to an impairment of liver regeneration. We designed a novel model of “repeated regeneration stimuli” in rats mimicking a “two-stage hepatectomy” with selective or complete biliary o...

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Main Authors: Beate Richter, Constanze Sänger, Franziska Mussbach, Hubert Scheuerlein, Utz Settmacher, Uta Dahmen
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-04-01
Colecção:Frontiers in Surgery
Assuntos:
hepatobiliary remodeling
occlusive cholestasis
regeneration stimuli
biliary decompression
experimental surgery
portal vein ligation
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fsurg.2022.799669/full
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