Methotrexate-related response on human peripheral blood mononuclear cells may be modulated by the Ala16Val-SOD2 gene polymorphism.

Methotrexate (MTX) is a folic acid antagonist used in high doses as an anti-cancer treatment and in low doses for the treatment of some autoimmune diseases. MTX use has been linked to oxidative imbalance, which may cause multi-organ toxicities that can be attenuated by antioxidant supplementation. D...

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Bibliografski detalji
Glavni autori: Fernanda Barbisan, Jéssica de Rosso Motta, Alexis Trott, Verônica Azzolin, Eduardo Bortoluzzi Dornelles, Matheus Marcon, Thaís Doeler Algarve, Marta Maria Medeiros Frescura Duarte, Clarice Pinheiro Mostardeiro, Taís Cristina Unfer, Karen Lilian Schott, Ivana Beatrice Mânica da Cruz
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science (PLoS) 2014-01-01
Serija:PLoS ONE
Online pristup:http://europepmc.org/articles/PMC4203676?pdf=render
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