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Conjugation of phosphonoacetic acid to nucleobase promotes a mechanism-based inhibition
Small molecule inhibitors have a powerful blocking action on viral polymerases. The bioavailability of the inhibitor, nevertheless, often raise a significant selectivity constraint and may substantially limit the efficacy of therapy. Phosphonoacetic acid has long been known to possess a restricted p...
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| Main Authors: | , , , , , |
|---|---|
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Taylor & Francis Group
2018-01-01
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| 叢編: | Journal of Enzyme Inhibition and Medicinal Chemistry |
| 主題: | |
| 在線閱讀: | http://dx.doi.org/10.1080/14756366.2017.1417275 |
| 標簽: |
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