Delayed Administration of Nintedanib Ameliorates Fibrosis Progression in CG-Induced Peritoneal Fibrosis Mouse Model

Background: A multiple-target tyrosine kinase inhibitor, nintedanib, which is approved for treatment of interstitial pulmonary disease, has been demonstrated to have anti-fibrotic activity outside of the lungs. We explored its therapeutic effect in a murine model of peritoneal fibrosis. Methods: Dai...

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Detalhes bibliográficos
Main Authors: Binbin Cui, Chao Yu, Shenglei Zhang, Xiying Hou, Yi Wang, Jun Wang, Shougang Zhuang, Feng Liu
Formato: Artigo
Idioma:Inglês
Publicado em: Karger Publishers 2022-04-01
Colecção:Kidney Diseases
Assuntos:
nintedanib
receptor tyrosine kinases
peritoneal fibrosis
epithelial-to-mesenchymal transition
inflammation
chlorhexidine gluconate
Acesso em linha:https://www.karger.com/Article/FullText/523852
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