Repeated-Dose Pharmacokinetics of Inhaled Ciclesonide (CIC-HFA) in Japanese Children with Bronchial Asthma: A Phase I Study

Background: Ciclesonide (CIC) is a highly safe, inhaled corticosteroid (ICS) that is converted into a pharmacologically active metabolite (des-isobutyryl-ciclesonide); this metabolite, in turn, exerts a local antiinflammatory effect on lung tissue. The present study was undertaken to analyze the pha...

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Auteurs principaux: Takahide Teramoto, Eiko Matsui, Toshiyuki Fukao, Kazuaki Sakai, Hiroshi Yonezawa, Zenichiro Kato, Hidenori Ohnishi, Hideo Kaneko, Naomi Kondo, Junichi Azuma, Sankei Nishima
Format: Artigo
Langue:Inglês
Publié: Elsevier 2012-01-01
Collection:Allergology International
Sujets:
bronchial asthma
ciclesonide
inhaled corticosteroid
pharmacokinetics
safety evaluation
Accès en ligne:http://www.sciencedirect.com/science/article/pii/S132389301530263X
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