Nutraceuticals/Drugs Promoting Mitophagy and Mitochondrial Biogenesis May Combat the Mitochondrial Dysfunction Driving Progression of Dry Age-Related Macular Degeneration

In patients with age-related macular degeneration (AMD), the crucial retinal pigment epithelial (RPE) cells are characterized by mitochondria that are structurally and functionally defective. Moreover, deficient expression of the mRNA-editing enzyme Dicer is noted specifically in these cells. This D...

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Detalhes bibliográficos
Main Authors: Lidianys María Lewis Luján, Mark F. McCarty, James J. Di Nicolantonio, Juan Carlos Gálvez Ruiz, Ema Carina Rosas-Burgos, Maribel Plascencia-Jatomea, Simon Bernard Iloki Assanga
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-05-01
Colecção:Nutrients
Assuntos:
nutraceuticals
age-related macular degeneration
mitochondrial biogenesis
Sirt1
AMPK
Nrf2
Acesso em linha:https://www.mdpi.com/2072-6643/14/9/1985
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